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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164113 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 250±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164113 | |||
| n/a | |||
| Name | BDBM50164113 | ||
| Synonyms: | 2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenoxy}-acetamide | CHEMBL369296 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H17Cl2N5O3 | ||
| Mol. Mass. | 470.308 | ||
| SMILES | Cn1c2nc(Nc3ccc(OCC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.92,-3.94,;2.92,-2.4,;1.59,-1.63,;.24,-2.4,;-1.09,-1.63,;-2.42,-2.41,;-3.75,-1.64,;-5.08,-2.43,;-6.41,-1.66,;-6.41,-.12,;-7.76,.65,;-7.76,2.19,;-9.09,2.96,;-10.42,2.19,;-9.09,4.5,;-5.08,.67,;-3.75,-.1,;-1.09,-.09,;.24,.68,;1.59,-.09,;2.9,.69,;4.25,-.05,;5.56,.7,;5.56,2.24,;4.21,2.99,;6.88,3.01,;8.22,2.26,;8.24,.72,;6.91,-.05,;6.91,-1.61,;4.25,-1.62,;5.58,-2.38,)| | ||
| Structure | 
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