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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164114 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 8600±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164114 | |||
| n/a | |||
| Name | BDBM50164114 | ||
| Synonyms: | 2,4-Dichloro-3-(8-methyl-7-oxo-2-phenylamino-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-benzamide | CHEMBL179806 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H15Cl2N5O2 | ||
| Mol. Mass. | 440.282 | ||
| SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(C(N)=O)c2Cl)c1=O |(.77,-4.02,;.77,-2.5,;-.56,-1.71,;-1.91,-2.5,;-3.24,-1.71,;-4.57,-2.5,;-5.9,-1.73,;-7.23,-2.5,;-8.58,-1.75,;-8.58,-.21,;-7.23,.58,;-5.9,-.19,;-3.24,-.17,;-1.91,.6,;-.56,-.17,;.75,.6,;2.08,-.15,;3.41,.61,;4.74,-.15,;4.76,-1.7,;6.07,.62,;6.07,2.16,;4.72,2.92,;4.71,4.47,;6.03,5.27,;3.36,5.23,;3.41,2.16,;2.05,2.91,;2.1,-1.71,;3.43,-2.46,)| | ||
| Structure | 
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