Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetWee1-like protein kinase
LigandBDBM50164118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304894 (CHEMBL829373)
IC50>50000±n/a nM
Citation Palmer, BDSmaill, JBRewcastle, GWDobrusin, EMKraker, AMoore, CWSteinkampf, RWDenny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50164118
n/a
NameBDBM50164118
Synonyms:6-(2-Chloro-6-trifluoromethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL360698
TypeSmall organic molecule
Emp. Form.C21H14ClF3N4O
Mol. Mass.430.81
SMILESCn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2C(F)(F)F)c1=O |(.75,-3.34,;.75,-1.8,;-.6,-1.03,;-1.93,-1.82,;-3.26,-1.03,;-4.59,-1.82,;-5.93,-1.03,;-7.25,-1.83,;-8.58,-1.07,;-8.59,.48,;-7.25,1.26,;-5.92,.49,;-3.26,.51,;-1.93,1.28,;-.6,.51,;.73,1.28,;2.06,.51,;3.39,1.3,;3.39,2.82,;2.04,3.59,;4.7,3.61,;6.05,2.85,;6.05,1.31,;4.72,.53,;4.74,-1.01,;6.28,-1.01,;3.65,.09,;4.72,-2.55,;2.08,-1.03,;3.41,-1.78,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: