Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50164118 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | >50000±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50164118 | |||
n/a | |||
Name | BDBM50164118 | ||
Synonyms: | 6-(2-Chloro-6-trifluoromethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL360698 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H14ClF3N4O | ||
Mol. Mass. | 430.81 | ||
SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2C(F)(F)F)c1=O |(.75,-3.34,;.75,-1.8,;-.6,-1.03,;-1.93,-1.82,;-3.26,-1.03,;-4.59,-1.82,;-5.93,-1.03,;-7.25,-1.83,;-8.58,-1.07,;-8.59,.48,;-7.25,1.26,;-5.92,.49,;-3.26,.51,;-1.93,1.28,;-.6,.51,;.73,1.28,;2.06,.51,;3.39,1.3,;3.39,2.82,;2.04,3.59,;4.7,3.61,;6.05,2.85,;6.05,1.31,;4.72,.53,;4.74,-1.01,;6.28,-1.01,;3.65,.09,;4.72,-2.55,;2.08,-1.03,;3.41,-1.78,)| | ||
Structure |