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TargetWee1-like protein kinase
LigandBDBM50164146
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304894 (CHEMBL829373)
IC50 3600±n/a nM
Citation Palmer, BDSmaill, JBRewcastle, GWDobrusin, EMKraker, AMoore, CWSteinkampf, RWDenny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50164146
n/a
NameBDBM50164146
Synonyms:CHEMBL178122 | N-[3,5-Dichloro-4-(8-methyl-7-oxo-2-phenylamino-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-phenyl]-acetamide
TypeSmall organic molecule
Emp. Form.C22H17Cl2N5O2
Mol. Mass.454.309
SMILESCC(=O)Nc1cc(Cl)c(c(Cl)c1)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(8.22,5.17,;6.89,4.4,;5.56,5.15,;6.91,2.86,;5.58,2.07,;5.58,.53,;4.25,-.24,;4.25,-1.78,;2.92,.53,;2.9,2.05,;1.56,2.82,;4.23,2.84,;1.59,-.26,;.26,.51,;-1.07,-.26,;-2.4,.51,;-3.73,-.29,;-3.73,-1.83,;-5.06,-2.6,;-6.41,-1.83,;-6.39,-.29,;-7.74,.48,;-9.08,-.29,;-9.05,-1.85,;-7.74,-2.6,;-2.4,-2.6,;-1.07,-1.8,;.26,-2.57,;.26,-4.11,;1.59,-1.8,;2.94,-2.57,)|
Structure
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