Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50164146 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | 3600±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50164146 | |||
n/a | |||
Name | BDBM50164146 | ||
Synonyms: | CHEMBL178122 | N-[3,5-Dichloro-4-(8-methyl-7-oxo-2-phenylamino-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-phenyl]-acetamide | ||
Type | Small organic molecule | ||
Emp. Form. | C22H17Cl2N5O2 | ||
Mol. Mass. | 454.309 | ||
SMILES | CC(=O)Nc1cc(Cl)c(c(Cl)c1)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(8.22,5.17,;6.89,4.4,;5.56,5.15,;6.91,2.86,;5.58,2.07,;5.58,.53,;4.25,-.24,;4.25,-1.78,;2.92,.53,;2.9,2.05,;1.56,2.82,;4.23,2.84,;1.59,-.26,;.26,.51,;-1.07,-.26,;-2.4,.51,;-3.73,-.29,;-3.73,-1.83,;-5.06,-2.6,;-6.41,-1.83,;-6.39,-.29,;-7.74,.48,;-9.08,-.29,;-9.05,-1.85,;-7.74,-2.6,;-2.4,-2.6,;-1.07,-1.8,;.26,-2.57,;.26,-4.11,;1.59,-1.8,;2.94,-2.57,)| | ||
Structure |