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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164150 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 41000±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164150 | |||
| n/a | |||
| Name | BDBM50164150 | ||
| Synonyms: | 6-(2,6-Bis-trifluoromethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181871 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H14F6N4O | ||
| Mol. Mass. | 464.3632 | ||
| SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(cccc2C(F)(F)F)C(F)(F)F)c1=O |(.54,-3.62,;.54,-2.08,;-.79,-1.31,;-2.14,-2.1,;-3.45,-1.34,;-4.78,-2.1,;-6.13,-1.34,;-6.11,.21,;-7.46,.97,;-8.78,.19,;-8.78,-1.35,;-7.44,-2.12,;-3.45,.23,;-2.14,.98,;-.79,.23,;.54,1,;1.87,.23,;3.2,1.02,;4.52,.23,;5.85,1.03,;5.85,2.57,;4.5,3.33,;3.18,2.54,;1.84,3.29,;.5,4.07,;1.07,1.96,;2.61,4.63,;4.53,-1.31,;6.07,-1.31,;4.13,-2.78,;5.62,-2.39,;1.87,-1.31,;3.22,-2.08,)| | ||
| Structure | 
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