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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164148 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 150±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164148 | |||
| n/a | |||
| Name | BDBM50164148 | ||
| Synonyms: | 6-(2,6-Dichloro-3-hydroxy-phenyl)-2-[4-(2-diethylamino-ethoxy)-phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181423 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27Cl2N5O3 | ||
| Mol. Mass. | 528.43 | ||
| SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)ccc(O)c4Cl)c(=O)n(C)c3n2)cc1 |(-7.25,6.08,;-7.25,4.54,;-8.58,3.77,;-9.89,4.53,;-9.89,6.07,;-8.56,2.22,;-7.23,1.46,;-7.21,-.08,;-5.9,-.85,;-4.57,-.05,;-3.21,-.84,;-3.22,-2.38,;-1.88,-3.13,;-.55,-2.38,;-.55,-.82,;.78,-.05,;2.12,-.82,;3.44,-.03,;4.77,-.82,;6.1,-.03,;7.43,-.8,;7.43,-2.34,;8.77,-.02,;8.76,1.53,;7.42,2.28,;7.38,3.82,;6.07,1.49,;4.74,2.26,;4.77,-2.34,;6.12,-3.13,;3.44,-3.13,;3.44,-4.67,;2.12,-2.36,;.78,-3.13,;-4.54,-3.16,;-5.87,-2.39,)| | ||
| Structure | 
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