Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Wee1-like protein kinase | ||
Ligand | BDBM50164159 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | 3700±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
| ||
BDBM50164159 | |||
n/a | |||
Name | BDBM50164159 | ||
Synonyms: | 6-(4-Amino-2,6-dichloro-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181982 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H15Cl2N5O | ||
Mol. Mass. | 412.272 | ||
SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cc(N)cc2Cl)c1=O |(1,-3.6,;1,-2.05,;-.33,-1.29,;-1.67,-2.08,;-3,-1.31,;-4.33,-2.08,;-5.69,-1.31,;-6.99,-2.08,;-8.32,-1.33,;-8.35,.23,;-7,1,;-5.66,.23,;-3,.23,;-1.67,1.02,;-.33,.26,;.99,1.02,;2.33,.27,;3.65,1.05,;3.64,2.58,;2.29,3.33,;4.95,3.36,;6.31,2.58,;7.64,3.38,;6.32,1.05,;4.99,.27,;4.99,-1.27,;2.33,-1.29,;3.67,-2.05,)| | ||
Structure |