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TargetWee1-like protein kinase
LigandBDBM50164159
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304894 (CHEMBL829373)
IC50 3700±n/a nM
Citation Palmer, BDSmaill, JBRewcastle, GWDobrusin, EMKraker, AMoore, CWSteinkampf, RWDenny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50164159
n/a
NameBDBM50164159
Synonyms:6-(4-Amino-2,6-dichloro-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181982
TypeSmall organic molecule
Emp. Form.C20H15Cl2N5O
Mol. Mass.412.272
SMILESCn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cc(N)cc2Cl)c1=O |(1,-3.6,;1,-2.05,;-.33,-1.29,;-1.67,-2.08,;-3,-1.31,;-4.33,-2.08,;-5.69,-1.31,;-6.99,-2.08,;-8.32,-1.33,;-8.35,.23,;-7,1,;-5.66,.23,;-3,.23,;-1.67,1.02,;-.33,.26,;.99,1.02,;2.33,.27,;3.65,1.05,;3.64,2.58,;2.29,3.33,;4.95,3.36,;6.31,2.58,;7.64,3.38,;6.32,1.05,;4.99,.27,;4.99,-1.27,;2.33,-1.29,;3.67,-2.05,)|
Structure
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