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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164156 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 69.0±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164156 | |||
| n/a | |||
| Name | BDBM50164156 | ||
| Synonyms: | 6-(2,6-Dichloro-phenyl)-8-methyl-2-{4-[3-(5H-tetrazol-5-yl)-propyl]-phenylamino}-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL178510 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H20Cl2N8O | ||
| Mol. Mass. | 507.375 | ||
| SMILES | Cn1c2nc(Nc3ccc(CCCC4N=NN=N4)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |c:14,16,(3.67,-4.58,;3.67,-3.04,;2.33,-2.27,;.99,-3.04,;-.34,-2.27,;-1.67,-3.06,;-3,-2.29,;-4.33,-3.06,;-5.66,-2.29,;-5.66,-.75,;-7.02,.02,;-7.02,1.56,;-8.35,2.33,;-8.35,3.87,;-7.11,4.78,;-7.58,6.23,;-9.14,6.23,;-9.61,4.76,;-4.33,.02,;-3,-.75,;-.34,-.73,;.99,.04,;2.33,-.73,;3.65,.05,;4.99,-.71,;6.31,.06,;6.31,1.6,;4.95,2.35,;7.63,2.37,;8.97,1.61,;8.98,.09,;7.65,-.71,;7.66,-2.25,;5,-2.26,;6.33,-3.02,)| | ||
| Structure | 
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