Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50164157 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | 50000±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50164157 | |||
n/a | |||
Name | BDBM50164157 | ||
Synonyms: | 6-(2,6-Dichloro-3-methyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL360689 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H16Cl2N4O | ||
Mol. Mass. | 411.284 | ||
SMILES | Cc1ccc(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(5.05,4.83,;5.05,3.29,;6.4,2.54,;6.4,1,;5.07,.23,;5.09,-1.33,;3.74,.98,;3.74,2.54,;2.39,3.28,;2.41,.23,;1.08,.97,;-.25,.19,;-1.58,.97,;-2.91,.19,;-2.91,-1.34,;-4.24,-2.13,;-5.57,-1.36,;-6.9,-2.13,;-8.23,-1.38,;-8.23,.16,;-6.9,.95,;-5.57,.18,;-1.58,-2.12,;-.25,-1.34,;1.1,-2.12,;1.1,-3.65,;2.43,-1.34,;3.76,-2.08,)| | ||
Structure |