| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase K |
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| Ligand | BDBM50164224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304809 (CHEMBL827899) |
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| IC50 | 17000±n/a nM |
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| Citation |  Leung-Toung, R; Tam, TF; Wodzinska, JM; Zhao, Y; Lowrie, J; Simpson, CD; Karimian, K; Spino, M 3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors. J Med Chem48:2266-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase K |
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| Name: | Protein-glutamine gamma-glutamyltransferase K |
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| Synonyms: | KTG | Protein-glutamine gamma-glutamyltransferase K | TGM1 | TGM1_HUMAN | Transglutaminase-1 (TG1) |
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| Type: | Protein |
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| Mol. Mass.: | 89778.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 817 |
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| Sequence: | MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDD
WGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSS
RSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTH
VIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPR
NEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDA
CLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVE
ILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDEN
MKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESI
KNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDI
TYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVML
INHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLV
DQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVT
LTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHG
VIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
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| BDBM50164224 |
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| n/a |
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| Name | BDBM50164224 |
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| Synonyms: | CHEMBL192921 | {Imidazo[1,2-d][1,2,4]thiadiazol-3-yl-[6-(2-nitro-benzenesulfonylamino)-hexyl]-amino}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N6O6S2 |
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| Mol. Mass. | 482.534 |
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| SMILES | OC(=O)CN(CCCCCCNS(=O)(=O)c1ccccc1[N+]([O-])=O)c1n[s+]c2[n-]ccn12 |
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| Structure | 
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