Ki Summary

Reaction Details

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Target

Coagulation factor XIII A chain

Ligand

BDBM50164226

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_304794 (CHEMBL877318)

IC50

910.0±n/a nM

Citation

Leung-Toung, R; Tam, TF; Wodzinska, JM; Zhao, Y; Lowrie, J; Simpson, CD; Karimian, K; Spino, M 3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors. J Med Chem48:2266-9 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Coagulation factor XIII A chain

Name:

Coagulation factor XIII A chain

Synonyms:

Coagulation factor XIII | F13A | F13A1 | F13A_HUMAN

Type:

PROTEIN

Mol. Mass.:

83261.29

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1475048

Residue:

732

Sequence:

MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM

BDBM50164226

n/a

Name

BDBM50164226

Synonyms:

CHEMBL193724 | N-[6-(Imidazo[1,2-d][1,2,4]thiadiazol-3-ylamino)-hexyl]-4-nitro-benzenesulfonamide

Type

Small organic molecule

Emp. Form.

C16H20N6O4S2

Mol. Mass.

424.498

SMILES

[O-][N+](=O)c1ccc(cc1)S(=O)(=O)NCCCCCCNc1n[s+]c2[n-]ccn12

Structure