Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50164230 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306714 (CHEMBL832299) |
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IC50 | 4.5±n/a nM |
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Citation | de Dios, A; Shih, C; López de Uralde, B; Sánchez, C; del Prado, M; Martín Cabrejas, LM; Pleite, S; Blanco-Urgoiti, J; Lorite, MJ; Nevill, CR; Bonjouklian, R; York, J; Vieth, M; Wang, Y; Magnus, N; Campbell, RM; Anderson, BD; McCann, DJ; Giera, DD; Lee, PA; Schultz, RM; Li, LC; Johnson, LM; Wolos, JA Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy. J Med Chem48:2270-3 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50164230 |
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n/a |
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Name | BDBM50164230 |
Synonyms: | 6-[5-(4-Fluoro-phenyl)-2-isopropyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine; compound with methanesulfonic acid | CHEMBL364925 |
Type | Small organic molecule |
Emp. Form. | C22H24FN5O2S |
Mol. Mass. | 441.522 |
SMILES | CC(C)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccc2nc(N)n(c2c1)S(=O)(=O)C(C)C |
Structure |
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