| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50164246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302593 (CHEMBL839553) |
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| Ki | 3±n/a nM |
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| Citation |  McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem48:2274-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39133.74 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_818502 |
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| Residue: | 353 |
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| Sequence: | MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50164246 |
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| n/a |
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| Name | BDBM50164246 |
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| Synonyms: | 1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-butyl]-urea | CHEMBL190842 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H35F4N5O |
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| Mol. Mass. | 557.6254 |
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| SMILES | CN1CCN(CCCCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)CC1 |
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| Structure | 
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