| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50164244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302591 (CHEMBL839551) |
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| Ki | 3±n/a nM |
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| Citation |  McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem48:2274-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50164244 |
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| n/a |
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| Name | BDBM50164244 |
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| Synonyms: | 3-(3-Chloro-4-fluoro-phenyl)-1-[4-(3-cyano-phenyl)-cyclohex-3-enyl]-1-(2-pyrrolidin-1-yl-ethyl)-urea | CHEMBL190875 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28ClFN4O |
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| Mol. Mass. | 466.978 |
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| SMILES | Fc1ccc(NC(=O)N(CCN2CCCC2)C2CCC(=CC2)c2cccc(c2)C#N)cc1Cl |c:20| |
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| Structure | 
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