| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50165010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302413 (CHEMBL828817) |
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| Ki | 35±n/a nM |
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| Citation |  Kaur, K; Aeron, S; Bruhaspathy, M; Shetty, SJ; Gupta, S; Hegde, LH; Silamkoti, AD; Mehta, A; Chugh, A; Gupta, JB; Sarma, PK; Kumar, N Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine. Bioorg Med Chem Lett15:2093-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66086.66 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M3 CHRM3 RAT::P08483 |
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| Residue: | 589 |
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| Sequence: | MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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| BDBM50165010 |
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| n/a |
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| Name | BDBM50165010 |
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| Synonyms: | CHEMBL192537 | Cyclohexyl-hydroxy-phenyl-acetic acid 4-(3-aza-bicyclo[3.1.0]hex-3-yl)-but-2-ynyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29NO3 |
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| Mol. Mass. | 367.4813 |
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| SMILES | OC(C1CCCCC1)(C(=O)OCC#CCN1CC2CC2C1)c1ccccc1 |
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| Structure | 
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