| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50165012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302412 (CHEMBL875203) |
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| Ki | 31±n/a nM |
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| Citation |  Kaur, K; Aeron, S; Bruhaspathy, M; Shetty, SJ; Gupta, S; Hegde, LH; Silamkoti, AD; Mehta, A; Chugh, A; Gupta, JB; Sarma, PK; Kumar, N Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine. Bioorg Med Chem Lett15:2093-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51555.53 |
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| Organism: | RAT |
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| Description: | P10980 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50165012 |
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| n/a |
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| Name | BDBM50165012 |
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| Synonyms: | CHEMBL192065 | Hydroxy-diphenyl-acetic acid 4-(3-aza-bicyclo[3.1.0]hex-3-yl)-but-2-ynyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23NO3 |
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| Mol. Mass. | 361.4336 |
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| SMILES | OC(C(=O)OCC#CCN1CC2CC2C1)(c1ccccc1)c1ccccc1 |
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| Structure | 
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