| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
|---|
| Ligand | BDBM50165553 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305068 (CHEMBL832700) |
|---|
| IC50 | 21±n/a nM |
|---|
| Citation |  Tatsuta, M; Kataoka, M; Yasoshima, K; Sakakibara, S; Shogase, Y; Shimazaki, M; Yura, T; Li, Y; Yamamoto, N; Gupta, J; Urbahns, K Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives. Bioorg Med Chem Lett15:2265-9 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gonadotropin-releasing hormone receptor |
|---|
| Name: | Gonadotropin-releasing hormone receptor |
|---|
| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37767.60 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1335047 |
|---|
| Residue: | 327 |
|---|
| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
|
|
|
|---|
| BDBM50165553 |
|---|
| n/a |
|---|
| Name | BDBM50165553 |
|---|
| Synonyms: | 6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzylsulfanyl)-3-propyl-3H-benzoimidazole-4-carboxylic acid [3-(benzyl-methyl-amino)-propyl]-amide | CHEMBL274002 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H45N7O5S |
|---|
| Mol. Mass. | 675.841 |
|---|
| SMILES | CCCn1c(SCc2cc(ccc2OC)[N+]([O-])=O)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NCCCN(C)Cc3ccccc3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
