Ki Summary

Reaction Details

Report a problem with these data

Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50165528

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_305068 (CHEMBL832700)

IC50

23±n/a nM

Citation

Tatsuta, M; Kataoka, M; Yasoshima, K; Sakakibara, S; Shogase, Y; Shimazaki, M; Yura, T; Li, Y; Yamamoto, N; Gupta, J; Urbahns, K Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives. Bioorg Med Chem Lett15:2265-9 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50165528

n/a

Name

BDBM50165528

Synonyms:

6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzylsulfanyl)-3-propyl-3H-benzoimidazole-4-carboxylic acid methylamide | CHEMBL440212

Type

Small organic molecule

Emp. Form.

C25H32N6O5S

Mol. Mass.

528.624

SMILES

CCCn1c(SCc2cc(ccc2OC)[N+]([O-])=O)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NC)c12

Structure