| Reaction Details |
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 | Report a problem with these data |
| Target | Heparanase |
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| Ligand | BDBM50165669 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305497 (CHEMBL831099) |
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| IC50 | 200±n/a nM |
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| Citation |  Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Phillips, DJ; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Bhaman, M; Felix, R; Stubberfield, CR; Turner, PR Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett15:2295-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heparanase |
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| Name: | Heparanase |
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| Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61167.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_327900 |
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| Residue: | 543 |
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| Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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| BDBM50165669 |
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| n/a |
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| Name | BDBM50165669 |
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| Synonyms: | (2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro-phenyl}-benzooxazol-5-yl)-acetic acid | 2-(2-(4-(3-(3-bromophenylamino)-3-oxoprop-1-enyl)-2-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid | CHEMBL193625 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16BrFN2O4 |
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| Mol. Mass. | 495.297 |
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| SMILES | OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(\C=C\C(=O)Nc2cccc(Br)c2)cc1F |
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| Structure | 
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