| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
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| Ligand | BDBM11056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305067 (CHEMBL832699) |
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| IC50 | 2.9±n/a nM |
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| Citation |  Sakashita, H; Kitajima, H; Nakamura, M; Akahoshi, F; Hayashi, Y 1-((S)-gamma-substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors. Bioorg Med Chem Lett15:2441-5 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 4 |
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| Name: | Dipeptidyl peptidase 4 |
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| Synonyms: | Bile canaliculus domain-specific membrane glycoprotein | CD_antigen=CD26 | Cd26 | DPP IV | DPP4_RAT | Dipeptidyl Peptidase IV (DPP-IV) | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 (DDPIV) | Dipeptidyl peptidase 4 60 kDa soluble form | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV 60 kDa soluble form | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dpp4 | GP110 glycoprotein | T-cell activation antigen CD26 |
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| Type: | Enzyme |
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| Mol. Mass.: | 88084.94 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 767 |
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| Sequence: | MKTPWKVLLGLLGVAALVTIITVPVVLLNKDEAAADSRRTYTLADYLKNTFRVKSYSLRW
VSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVK
QWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGHKLAYVWKNDIYVKIEPHLPS
HRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYS
DESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCD
VAWVSEDRISLQWLRRIQNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRPAEP
HFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYIS
NEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPGLPL
YTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKK
YPLLIDVYAGPCSQKADAAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLG
TLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRW
EYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQI
SKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLR
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| BDBM11056 |
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| n/a |
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| Name | BDBM11056 |
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| Synonyms: | (2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile | 2-cyanopyrrolidine 10a | CHEMBL381626 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N3O |
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| Mol. Mass. | 193.2456 |
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| SMILES | O=C([C@@H]1CCCN1)N1CCC[C@H]1C#N |r| |
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| Structure | 
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