Reaction Details |
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Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
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Ligand | BDBM50166478 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304867 (CHEMBL829244) |
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IC50 | 12000±n/a nM |
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Citation | Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylenolpyruvoylglucosamine reductase |
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Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
Synonyms: | MURB_STAAU | MurB (S. aureus) | UDP-N-acetylenolpyruvoylglucosamine reductase | murB |
Type: | Protein |
Mol. Mass.: | 33791.48 |
Organism: | Staphylococcus aureus (Firmicutes) |
Description: | S. aureus MurB |
Residue: | 307 |
Sequence: | MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
GEHPKES
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BDBM50166478 |
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n/a |
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Name | BDBM50166478 |
Synonyms: | 1,2-Bis-(4-chloro-phenyl)-4-(6-phenyl-hexyl)-pyrazolidine-3,5-dione | CHEMBL373076 |
Type | Small organic molecule |
Emp. Form. | C27H26Cl2N2O2 |
Mol. Mass. | 481.414 |
SMILES | Oc1c(CCCCCCc2ccccc2)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1 |
Structure |
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