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TargetUDP-N-acetylenolpyruvoylglucosamine reductase
LigandBDBM50166478
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304867 (CHEMBL829244)
IC50 12000±n/a nM
Citation Kutterer, KMDavis, JMSingh, GYang, YHu, WSeverin, ARasmussen, BAKrishnamurthy, GFailli, AKatz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylenolpyruvoylglucosamine reductase
Name:UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms:MURB_STAAU | MurB (S. aureus) | UDP-N-acetylenolpyruvoylglucosamine reductase | murB
Type:Protein
Mol. Mass.:33791.48
Organism:Staphylococcus aureus (Firmicutes)
Description:S. aureus MurB
Residue:307
Sequence:
MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
GEHPKES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50166478
n/a
NameBDBM50166478
Synonyms:1,2-Bis-(4-chloro-phenyl)-4-(6-phenyl-hexyl)-pyrazolidine-3,5-dione | CHEMBL373076
TypeSmall organic molecule
Emp. Form.C27H26Cl2N2O2
Mol. Mass.481.414
SMILESOc1c(CCCCCCc2ccccc2)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1
Structure
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