| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Ligand | BDBM50166479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304867 (CHEMBL829244) |
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| IC50 | >50000±n/a nM |
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| Citation |  Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Synonyms: | MURB_STAAU | MurB (S. aureus) | UDP-N-acetylenolpyruvoylglucosamine reductase | murB |
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| Type: | Protein |
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| Mol. Mass.: | 33791.48 |
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| Organism: | Staphylococcus aureus (Firmicutes) |
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| Description: | S. aureus MurB |
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| Residue: | 307 |
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| Sequence: | MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
GEHPKES
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| BDBM50166479 |
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| n/a |
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| Name | BDBM50166479 |
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| Synonyms: | 4-[2-(Benzyl-ethyl-amino)-ethyl]-1,2-bis-(4-chloro-phenyl)-pyrazolidine-3,5-dione | CHEMBL365523 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25Cl2N3O2 |
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| Mol. Mass. | 482.402 |
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| SMILES | CCN(CCc1c(O)n(-c2ccc(Cl)cc2)n(-c2ccc(Cl)cc2)c1=O)Cc1ccccc1 |
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| Structure | 
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