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TargetUDP-N-acetylenolpyruvoylglucosamine reductase
LigandBDBM50166486
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304764 (CHEMBL829361)
IC50 11000±n/a nM
Citation Kutterer, KMDavis, JMSingh, GYang, YHu, WSeverin, ARasmussen, BAKrishnamurthy, GFailli, AKatz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylenolpyruvoylglucosamine reductase
Name:UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms:MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB
Type:Protein
Mol. Mass.:37848.05
Organism:Escherichia coli K-12 (Enterobacteria)
Description:E. coli MurB
Residue:342
Sequence:
MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
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  Blast E-value cutoff:
BDBM50166486
n/a
NameBDBM50166486
Synonyms:1,2-Bis-(4-chloro-phenyl)-4-(2,4-dichloro-benzyl)-pyrazolidine-3,5-dione | CHEMBL191919
TypeSmall organic molecule
Emp. Form.C22H14Cl4N2O2
Mol. Mass.480.171
SMILESOc1c(Cc2ccc(Cl)cc2Cl)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1
Structure
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