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TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase
LigandBDBM50166495
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304763 (CHEMBL829360)
IC50 42300±n/a nM
Citation Kutterer, KMDavis, JMSingh, GYang, YHu, WSeverin, ARasmussen, BAKrishnamurthy, GFailli, AKatz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Name:UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:Protein
Mol. Mass.:44814.62
Organism:Escherichia coli K-12 (Enterobacteria)
Description:E. coli MurA
Residue:419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
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  Blast E-value cutoff:
BDBM50166495
n/a
NameBDBM50166495
Synonyms:1,2-Bis-(4-chloro-phenyl)-4-(5-phenyl-pentyl)-pyrazolidine-3,5-dione | CHEMBL371841
TypeSmall organic molecule
Emp. Form.C26H24Cl2N2O2
Mol. Mass.467.387
SMILESOc1c(CCCCCc2ccccc2)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1
Structure
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