Reaction Details |
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Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
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Ligand | BDBM50166496 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304764 (CHEMBL829361) |
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IC50 | 11000±n/a nM |
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Citation | Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett15:2527-31 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylenolpyruvoylglucosamine reductase |
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Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
Synonyms: | MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB |
Type: | Protein |
Mol. Mass.: | 37848.05 |
Organism: | Escherichia coli K-12 (Enterobacteria) |
Description: | E. coli MurB |
Residue: | 342 |
Sequence: | MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
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BDBM50166496 |
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n/a |
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Name | BDBM50166496 |
Synonyms: | 1-{4-[1,2-Bis-(4-chloro-phenyl)-3,5-dioxo-pyrazolidin-4-ylmethyl]-phenyl}-cyclohexa-2,4-dienecarbonitrile | CHEMBL195201 |
Type | Small organic molecule |
Emp. Form. | C29H21Cl2N3O2 |
Mol. Mass. | 514.402 |
SMILES | Oc1c(Cc2ccc(cc2)C2(CC=CC=C2)C#N)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1 |c:13,15| |
Structure |
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