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TargetMelanocortin receptor 4
LigandBDBM50166523
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303456
Ki 1.5±n/a nM
Citation Pontillo JTran JAMarkison SJoppa MFleck BAMarinkovic DArellano MTucci FCLanier MNelson JSaunders JHoare SRFoster ACChen C A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice. Bioorg Med Chem Lett 15:2541-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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  Blast E-value cutoff:
BDBM50166523
n/a
NameBDBM50166523
Synonyms:CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-ethyl]-amide
TypeSmall organic molecule
Emp. Form.C31H37Cl2N5O2S
Mol. Mass.614.629
SMILESClc1ccc(C[C@@H](NC(=O)N2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Structure
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