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TargetCathepsin (B and K)
LigandBDBM50167288
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303351
Ki 0.250000±n/a nM
Citation Barrett DGDeaton DNHassell AMMcFadyen RBMiller ABMiller LRPayne JAShewchuk LMWillard DHWright LL Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 15:3039-43 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin (B and K)
Name:Cathepsin (B and K)
Synonyms:APP secretase | APPS | Cathepsin B | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50167288
n/a
NameBDBM50167288
Synonyms:(1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarboxylate | CHEMBL191558
TypeSmall organic molecule
Emp. Form.C13H17N3O2
Mol. Mass.247.293
SMILESCC[C@@H](Cc1ccccc1)OC(=O)NN(C)C#N
Structure
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