| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50167404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302561 (CHEMBL839523) |
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| Ki | 27±n/a nM |
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| Citation |  Puccetti, L; Fasolis, G; Vullo, D; Chohan, ZH; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorg Med Chem Lett15:3096-101 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50167404 |
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| n/a |
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| Name | BDBM50167404 |
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| Synonyms: | 4-((4-oxo-4H-chromen-3-yl)methyleneamino)-6-(trifluoromethyl)benzene-1,3-disulfonamide | 4-[(4-Oxo-4H-chromen-3-ylmethylene)-amino]-6-trifluoromethyl-benzene-1,3-disulfonic acid diamide | CHEMBL193924 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F3N3O6S2 |
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| Mol. Mass. | 475.419 |
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| SMILES | NS(=O)(=O)c1cc(c(cc1\N=C\c1coc2ccccc2c1=O)C(F)(F)F)S(N)(=O)=O |
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| Structure | 
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