Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50167416 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302561 (CHEMBL839523) |
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Ki | 50±n/a nM |
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Citation | Puccetti, L; Fasolis, G; Vullo, D; Chohan, ZH; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorg Med Chem Lett15:3096-101 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50167416 |
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n/a |
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Name | BDBM50167416 |
Synonyms: | 4-(((6-methyl-4-oxo-4H-chromen-3-yl)methyleneamino)methyl)benzenesulfonamide | 4-({[1-(6-Methyl-4-oxo-4H-chromen-3-yl)-meth-(E)-ylidene]-amino}-methyl)-benzenesulfonamide | CHEMBL193907 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O4S |
Mol. Mass. | 356.396 |
SMILES | Cc1ccc2occ(\C=N\Cc3ccc(cc3)S(N)(=O)=O)c(=O)c2c1 |
Structure |
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