| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50167418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302531 (CHEMBL827383) |
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| Ki | 41±n/a nM |
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| Citation |  Puccetti, L; Fasolis, G; Vullo, D; Chohan, ZH; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorg Med Chem Lett15:3096-101 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50167418 |
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| n/a |
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| Name | BDBM50167418 |
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| Synonyms: | 4-(2-((6-methyl-4-oxo-4H-chromen-3-yl)methyleneamino)pyrimidin-4-ylamino)benzenesulfonamide | 4-(2-{[1-(6-Methyl-4-oxo-4H-chromen-3-yl)-meth-(E)-ylidene]-amino}-pyrimidin-4-ylamino)-benzenesulfonamide | CHEMBL372497 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N5O4S |
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| Mol. Mass. | 435.456 |
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| SMILES | Cc1ccc2occ(\C=N\c3nccc(Nc4ccc(cc4)S(N)(=O)=O)n3)c(=O)c2c1 |
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| Structure | 
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