| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50167552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306352 (CHEMBL828171) |
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| IC50 | 2.4±n/a nM |
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| Citation |  Souers, AJ; Gao, J; Wodka, D; Judd, AS; Mulhern, MM; Napier, JJ; Brune, ME; Bush, EN; Brodjian, SJ; Dayton, BD; Shapiro, R; Hernandez, LE; Marsh, KC; Sham, HL; Collins, CA; Kym, PR Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorg Med Chem Lett15:2752-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39133.74 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_818502 |
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| Residue: | 353 |
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| Sequence: | MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50167552 |
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| n/a |
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| Name | BDBM50167552 |
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| Synonyms: | 1-[1-(2-Cyclopentylamino-ethyl)-1H-indazol-5-yl]-3-(4-phenoxy-phenyl)-urea | CHEMBL196599 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N5O2 |
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| Mol. Mass. | 455.5515 |
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| SMILES | O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc2n(CCNC3CCCC3)ncc2c1 |
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| Structure | 
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