Reaction Details |
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Target | Coagulation factor VII |
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Ligand | BDBM50167835 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304953 (CHEMBL827832) |
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IC50 | 20±n/a nM |
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Citation | Schweitzer, BA; Neumann, WL; Rahman, HK; Kusturin, CL; Sample, KR; Poda, GI; Kurumbail, RG; Stevens, AM; Stegeman, RA; Stallings, WC; South, MS Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett15:3006-11 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor VII |
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Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50167835 |
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n/a |
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Name | BDBM50167835 |
Synonyms: | 3-amino-N-[(2R)-butan-2-yl]-5-[1-({[(4-carbamimidoyl-2-{[2-(morpholin-4-yl)ethyl]carbamoyl}phenyl)methyl]carbamoyl}methyl)-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl]benzamide | CHEMBL189165 |
Type | Small organic molecule |
Emp. Form. | C35H48N10O5 |
Mol. Mass. | 688.8196 |
SMILES | CC[C@@H](C)NC(=O)c1cc(N)cc(c1)-c1cnc(NC(C)C)c(=O)n1CC(=O)NCc1ccc(cc1C(=O)NCCN1CCOCC1)C(N)=N |
Structure |
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