| Reaction Details |
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 | Report a problem with these data |
| Target | alpha-1,2-Mannosidase |
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| Ligand | BDBM50168991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302738 (CHEMBL838685) |
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| Ki | 1350±n/a nM |
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| Citation |  Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem48:4237-46 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| alpha-1,2-Mannosidase |
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| Name: | alpha-1,2-Mannosidase |
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| Synonyms: | Alpha-mannosidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65344.50 |
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| Organism: | Glycine max |
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| Description: | ChEMBL_32380 |
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| Residue: | 578 |
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| Sequence: | MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISE
LQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAW
GSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDF
NKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLS
HGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLP
IYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIR
RSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTC
YNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNI
FQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNT
EAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
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| BDBM50168991 |
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| n/a |
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| Name | BDBM50168991 |
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| Synonyms: | (2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol | CHEMBL425364 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N2O4 |
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| Mol. Mass. | 282.3355 |
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| SMILES | OCC(NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O)c1ccccc1 |
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| Structure | 
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