Reaction Details |
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Target | Methionine aminopeptidase 1 |
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Ligand | BDBM50169669 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_311969 (CHEMBL834386) |
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IC50 | 250±n/a nM |
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Citation | Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett15:3732-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine aminopeptidase 1 |
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Name: | Methionine aminopeptidase 1 |
Synonyms: | MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1 |
Type: | PROTEIN |
Mol. Mass.: | 43382.92 |
Organism: | Saccharomyces cerevisiae |
Description: | ChEMBL_10701 |
Residue: | 387 |
Sequence: | MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYK
AHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQR
NDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYP
SPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGEN
ISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFF
HCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHT
LLVTEHGVEILTARNKKSPGGPRQRIK
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BDBM50169669 |
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n/a |
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Name | BDBM50169669 |
Synonyms: | 5-(Cyclobutanecarbonyl-amino)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL360955 |
Type | Small organic molecule |
Emp. Form. | C12H12N4O2S2 |
Mol. Mass. | 308.379 |
SMILES | O=C(Nc1scnc1C(=O)Nc1nccs1)C1CCC1 |
Structure |
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