Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMethionine aminopeptidase 1
LigandBDBM50169670
Substrate/Competitorn/a
Meas. Tech.ChEMBL_311969 (CHEMBL834386)
IC50 660.0±n/a nM
Citation Cui, YMHuang, QQXu, JChen, LLLi, JYYe, QZLi, JNan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett15:3732-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine aminopeptidase 1
Name:Methionine aminopeptidase 1
Synonyms:MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1
Type:PROTEIN
Mol. Mass.:43382.92
Organism:Saccharomyces cerevisiae
Description:ChEMBL_10701
Residue:387
Sequence:
MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYK
AHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQR
NDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYP
SPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGEN
ISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFF
HCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHT
LLVTEHGVEILTARNKKSPGGPRQRIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50169670
n/a
NameBDBM50169670
Synonyms:5-Phenethyl-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL179543
TypeSmall organic molecule
Emp. Form.C15H13N3OS2
Mol. Mass.315.413
SMILESO=C(Nc1nccs1)c1ncsc1CCc1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: