Reaction Details |
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Target | Casein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2 |
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Ligand | BDBM50169892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304706 (CHEMBL828005) |
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IC50 | 3050±n/a nM |
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Citation | Kuo, GH; Deangelis, A; Emanuel, S; Wang, A; Zhang, Y; Connolly, PJ; Chen, X; Gruninger, RH; Rugg, C; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem48:4535-46 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Casein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2 |
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Name: | Casein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2 |
Synonyms: | Casein kinase I |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 304706 |
Components: | This complex has 5 components. |
Component 1 |
Name: | Casein kinase I isoform gamma-1 |
Synonyms: | CKI-gamma 1 | CSNK1G1 | Casein kinase I | Casein kinase I gamma 1 isoform | Casein kinase I isoform gamma-1 | KC1G1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 48530.93 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774608 |
Residue: | 422 |
Sequence: | MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL
GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL
LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE
HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE
KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP
SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR
HK
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Component 2 |
Name: | Casein kinase I isoform delta |
Synonyms: | CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta) |
Type: | Enzyme |
Mol. Mass.: | 47356.76 |
Organism: | Homo sapiens (Human) |
Description: | P48730 |
Residue: | 415 |
Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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Component 3 |
Name: | Casein kinase I isoform epsilon |
Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
Type: | Protein |
Mol. Mass.: | 47340.25 |
Organism: | Homo sapiens (Human) |
Description: | P49674 |
Residue: | 416 |
Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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Component 4 |
Name: | Casein kinase I isoform gamma-2 |
Synonyms: | CK1G2 | CSNK1G2 | Casein kinase I | Casein kinase I gamma 2 | KC1G2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 47475.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774313 |
Residue: | 415 |
Sequence: | MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGEL
RLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLE
LLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKR
QHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH
MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF
EKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSK
NQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
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Component 5 |
Name: | Casein kinase I isoform alpha |
Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 38936.59 |
Organism: | Homo sapiens (Human) |
Description: | P48729 |
Residue: | 337 |
Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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BDBM50169892 |
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n/a |
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Name | BDBM50169892 |
Synonyms: | 3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}-propan-1-ol | CHEMBL191336 |
Type | Small organic molecule |
Emp. Form. | C17H17ClN6O |
Mol. Mass. | 356.809 |
SMILES | OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1 |
Structure |
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