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TargetRNA-directed RNA polymerase
LigandBDBM50169932
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305448 (CHEMBL830123)
IC50 17±n/a nM
Citation Harper, SAvolio, SPacini, BDi Filippo, MAltamura, STomei, LPaonessa, GDi Marco, SCarfi, AGiuliano, CPadron, JBonelli, FMigliaccio, GDe Francesco, RLaufer, RRowley, MNarjes, F Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase. J Med Chem48:4547-57 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50169932
n/a
NameBDBM50169932
Synonyms:2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(dimethylcarbamoylmethyl-methyl-carbamoyl)-methyl]-1H-indole-6-carboxylic acid | CHEMBL191059
TypeSmall organic molecule
Emp. Form.C28H32ClN3O4
Mol. Mass.510.024
SMILESCN(C)C(=O)CN(C)C(=O)Cn1c(c(C2CCCCC2)c2ccc(cc12)C(O)=O)-c1ccc(Cl)cc1
Structure
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