Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRNA-directed RNA polymerase
LigandBDBM50169900
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305448 (CHEMBL830123)
IC50 78±n/a nM
Citation Harper, SAvolio, SPacini, BDi Filippo, MAltamura, STomei, LPaonessa, GDi Marco, SCarfi, AGiuliano, CPadron, JBonelli, FMigliaccio, GDe Francesco, RLaufer, RRowley, MNarjes, F Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase. J Med Chem48:4547-57 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50169900
n/a
NameBDBM50169900
Synonyms:2-(4-Chloro-3-dimethylaminomethyl-phenyl)-3-cyclohexyl-1-dimethylcarbamoylmethyl-1H-indole-6-carboxylic acid | CHEMBL372656
TypeSmall organic molecule
Emp. Form.C28H34ClN3O3
Mol. Mass.496.041
SMILESCN(C)Cc1cc(ccc1Cl)-c1c(C2CCCCC2)c2ccc(cc2n1CC(=O)N(C)C)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: