Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50169952

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303211 (CHEMBL829836)

8.9±n/a nM

Citation

Lu, D; Meng, Z; Thakur, GA; Fan, P; Steed, J; Tartal, CL; Hurst, DP; Reggio, PH; Deschamps, JR; Parrish, DA; George, C; Järbe, TU; Lamb, RJ; Makriyannis, A Adamantyl cannabinoids: a novel class of cannabinergic ligands. J Med Chem48:4576-85 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CNR2_MOUSE | Cannabinoid CB2 receptor | Cannabinoid receptor | Cannabinoid receptor 2 | Cnr2 | mCB2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38220.43

Organism:

MOUSE

Description:

P47936

Residue:

347

Sequence:

MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILS
SRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTAS
VGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCS
ELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLD
VRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYA
LRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT

BDBM50169952

n/a

Name

BDBM50169952

Synonyms:

(6aR,10aR)-3-Adamantan-2-ylidenemethyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | AM-755 | CHEMBL191324

Type

Small organic molecule

Emp. Form.

C27H34O2

Mol. Mass.

390.5577

SMILES

CC1=CC[C@@H]2[C@@H](C1)c1c(O)cc(C=C3C4CC5CC(C4)CC3C5)cc1OC2(C)C |r,wU:5.7,wD:4.3,t:1,TLB:12:13:15:19.17.18,THB:17:16:13:19.18.20,17:18:15.16.22:13,20:18:15:22.21.13,20:21:15:19.17.18,(22.24,-4.11,;22.24,-5.66,;20.9,-6.44,;20.9,-7.98,;22.24,-8.75,;23.57,-7.98,;23.57,-6.44,;24.9,-8.75,;26.23,-7.99,;26.24,-6.45,;27.55,-8.76,;27.55,-10.31,;28.88,-11.09,;30.23,-10.32,;30.23,-8.83,;29.03,-7.55,;30.54,-7.97,;31.95,-7.4,;32.97,-8.69,;31.57,-8.34,;32.98,-10.22,;31.58,-10.8,;30.53,-9.56,;26.21,-11.06,;24.89,-10.29,;23.56,-11.06,;22.23,-10.28,;20.73,-10.68,;21.82,-11.77,)|

Structure