| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50170294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305658 (CHEMBL829516) |
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| IC50 | 0.980000±n/a nM |
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| Citation |  Wu, J; Rush, TS; Hotchandani, R; Du, X; Geck, M; Collins, E; Xu, ZB; Skotnicki, J; Levin, JI; Lovering, FE Identification of potent and selective MMP-13 inhibitors. Bioorg Med Chem Lett15:4105-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP13 | MMP13_BOVIN | Matrix metalloproteinase 13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53910.47 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_305658 |
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| Residue: | 471 |
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| Sequence: | MHPRVLAGFLFFSWTACWSLPLPSDGDSEDLSEEDFQFAESYLKSYYYPQNPAGILKKTA
ASSVIDRLREMQSFFGLEVTGRLDDNTLDIMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDLTHSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIMISFGTKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPYSKHPKTPDKCDPSLSLDAITSLRGET
LIFKDRFFWRLHPQQVEAELFLTKSFGPELPNRIDAAYEHPSHDLIFIFRGRKFWALSGY
DILEDYPKKISELGFPKHVKKISAALHFEDSGKTLFFSENQVWSYDDTNHVMDKDYPRLI
EEVFPGIGDKVDAVYQKNGYIYFFNGPIQFEYSIWSNRIVRVMTTNSLLWC
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| BDBM50170294 |
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| n/a |
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| Name | BDBM50170294 |
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| Synonyms: | (S)-2-{4'-[(5-Acetylamino-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | CHEMBL362522 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O7S |
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| Mol. Mass. | 549.595 |
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| SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NC(C)=O)ccc3o2)cc1)C(O)=O |
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| Structure | 
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