Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMetabotropic glutamate receptor 2
LigandBDBM50170321
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304368
EC50 779±n/a nM
Citation Govek SPBonnefous CHutchinson JHKamenecka TMcQuiston JPracitto RZhao LXGardner MFJames JKDaggett LPRowe BASchaffhauser HBristow LJCampbell UCRodriguez DEVernier JM Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia. Bioorg Med Chem Lett 15:4068-72 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GRM2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | mGluR2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50170321
n/a
NameBDBM50170321
Synonyms:1-(2,2-Dimethyl-propyl)-4-propyl-5-{4-[4-(1H-tetrazol-5-yl)-phenoxy]-but-2-enyloxy}-1H-indole | CHEMBL189623
TypeSmall organic molecule
Emp. Form.C27H33N5O2
Mol. Mass.459.5832
SMILESCCCc1c(OC\C=C\COc2ccc(cc2)-c2nnn[nH]2)ccc2n(CC(C)(C)C)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: