| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50170380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304990 (CHEMBL828603) |
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| IC50 | 550±n/a nM |
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| Citation |  Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives. Bioorg Med Chem Lett15:4130-5 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43382.92 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_10701 |
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| Residue: | 387 |
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| Sequence: | MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYK
AHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQR
NDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYP
SPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGEN
ISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFF
HCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHT
LLVTEHGVEILTARNKKSPGGPRQRIK
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| BDBM50170380 |
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| n/a |
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| Name | BDBM50170380 |
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| Synonyms: | Benzyloxy-acetic acid 2-[4-(thiazol-2-ylcarbamoyl)-thiazol-5-yl]-ethyl ester | CHEMBL189127 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N3O4S2 |
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| Mol. Mass. | 403.475 |
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| SMILES | O=C(COCc1ccccc1)OCCc1scnc1C(=O)Nc1nccs1 |
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| Structure | 
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