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TargetProstanoid IP receptor
LigandBDBM50171474
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303625
Ki 210±n/a nM
Citation Ohno MMiyamoto MHoshi KTakeda TYamada NOhtake A Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives. J Med Chem 48:5279-94 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostanoid IP receptor
Name:Prostanoid IP receptor
Synonyms:PGI receptor | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40968.22
Organism:Homo sapiens (Human)
Description:The membranes prepared from human platelet were used in binding assay.
Residue:386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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BDBM50171474
n/a
NameBDBM50171474
Synonyms:CHEMBL192662 | [3-[2-(1,1-Diphenyl-ethylsulfanyl)-ethyl]-2-(2-hydroxy-ethyl)-benzofuran-7-yloxy]-acetic acid
TypeSmall organic molecule
Emp. Form.C28H28O5S
Mol. Mass.476.584
SMILESCC(SCCc1c(CCO)oc2c(OCC(O)=O)cccc12)(c1ccccc1)c1ccccc1
Structure
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