| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor |
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| Ligand | BDBM50171580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321352 |
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| IC50 | 4±n/a nM |
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| Citation |  Vasudevan A; LaMarche MJ; Blackburn C; Che JL; Luchaco-Cullis CA; Lai S; Marsilje TH; Patane MA; Souers AJ; Wodka D; Geddes B; Chen S; Brodjian S; Falls DH; Dayton BD; Bush E; Brune M; Shapiro RD; Marsh KC; Hernandez LE; Sham HL; Collins CA; Kym PR Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists. Bioorg Med Chem Lett 15:4174-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor |
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| Name: | Melanin-concentrating hormone receptor |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50171580 |
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| n/a |
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| Name | BDBM50171580 |
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| Synonyms: | CHEMBL196277 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-5-chloro-2-[(thiazol-4-ylmethyl)-amino]-nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN5O3S |
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| Mol. Mass. | 485.986 |
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| SMILES | Clc1cnc(NCc2cscn2)c(c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1 |
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| Structure | 
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