Reaction Details | |||
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Target | Thyroid hormone receptor beta | ||
Ligand | BDBM50171802 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_321321 (CHEMBL882591) | ||
IC50 | 0.3±n/a nM | ||
Citation | Hangeland, JJ; Friends, TJ; Doweyko, AM; Mellström, K; Sandberg, J; Grynfarb, M; Ryono, DE A new class of high affinity thyromimetics containing a phenyl-naphthylene core. Bioorg Med Chem Lett15:4579-84 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Thyroid hormone receptor beta | |||
Name: | Thyroid hormone receptor beta | ||
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta | ||
Type: | Receptor | ||
Mol. Mass.: | 52793.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. | ||
Residue: | 461 | ||
Sequence: |
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BDBM50171802 | |||
n/a | |||
Name | BDBM50171802 | ||
Synonyms: | CHEMBL196642 | N-[3,5-Dichloro-4-(5-isopropyl-6-methoxy-naphthalen-1-yl)-phenyl]-malonamic acid | ||
Type | Small organic molecule | ||
Emp. Form. | C23H21Cl2NO4 | ||
Mol. Mass. | 446.323 | ||
SMILES | COc1ccc2c(cccc2c1C(C)C)-c1c(Cl)cc(NC(=O)CC(O)=O)cc1Cl |(1.71,1.66,;1.71,.12,;3.04,-.65,;4.37,.13,;5.72,-.64,;5.72,-2.19,;7.05,-2.96,;7.05,-4.49,;5.7,-5.27,;4.37,-4.5,;4.37,-2.96,;3.04,-2.19,;1.71,-2.96,;.38,-2.19,;1.71,-4.5,;8.38,-2.18,;9.71,-2.95,;9.71,-4.49,;11.04,-2.18,;11.04,-.64,;12.37,.14,;13.7,-.63,;15.05,.16,;13.72,-2.17,;15.06,-2.92,;15.06,-4.46,;16.39,-2.15,;9.71,.13,;8.38,-.64,;7.05,.13,)| | ||
Structure |