Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM16312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305507 (CHEMBL831109) |
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IC50 | 2000±n/a nM |
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Citation | El-Kabbani, O; Carbone, V; Darmanin, C; Oka, M; Mitschler, A; Podjarny, A; Schulze-Briese, C; Chung, RP Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. J Med Chem48:5536-42 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM16312 |
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n/a |
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Name | BDBM16312 |
Synonyms: | (4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | CHEMBL266497 | Sorbinil |
Type | Small organic molecule |
Emp. Form. | C11H9FN2O3 |
Mol. Mass. | 236.1992 |
SMILES | Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |r| |
Structure |
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