Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50172277 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_320876 (CHEMBL884801) |
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Ki | 13±n/a nM |
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Citation | Cole, DC; Lennox, WJ; Stock, JR; Ellingboe, JW; Mazandarani, H; Smith, DL; Zhang, G; Tawa, GJ; Schechter, LE Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists. Bioorg Med Chem Lett15:4780-5 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50172277 |
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n/a |
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Name | BDBM50172277 |
Synonyms: | 1-(2-Chloro-benzenesulfonyl)-3-(1,2,5,6-tetrahydro-pyridin-3-yl)-1H-indole | CHEMBL194904 |
Type | Small organic molecule |
Emp. Form. | C19H17ClN2O2S |
Mol. Mass. | 372.868 |
SMILES | Clc1ccccc1S(=O)(=O)n1cc(C2=CCCNC2)c2ccccc12 |t:14| |
Structure |
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