Reaction Details |
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Target | Cytochrome P450 2C19 |
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Ligand | BDBM50201124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321410 (CHEMBL881941) |
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IC50 | 26±n/a nM |
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Citation | Wittman, M; Carboni, J; Attar, R; Balasubramanian, B; Balimane, P; Brassil, P; Beaulieu, F; Chang, C; Clarke, W; Dell, J; Eummer, J; Frennesson, D; Gottardis, M; Greer, A; Hansel, S; Hurlburt, W; Jacobson, B; Krishnananthan, S; Lee, FY; Li, A; Lin, TA; Liu, P; Ouellet, C; Sang, X; Saulnier, MG; Stoffan, K; Sun, Y; Velaparthi, U; Wong, H; Yang, Z; Zimmermann, K; Zoeckler, M; Vyas, D Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem48:5639-43 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C19 |
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Name: | Cytochrome P450 2C19 |
Synonyms: | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
Type: | Enzyme |
Mol. Mass.: | 55935.47 |
Organism: | Homo sapiens (Human) |
Description: | P33261 |
Residue: | 490 |
Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50201124 |
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n/a |
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Name | BDBM50201124 |
Synonyms: | 3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one | 4-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(6-imidazol-1-yl-4-methyl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one | CHEMBL231306 |
Type | Small organic molecule |
Emp. Form. | C24H21ClN6O2 |
Mol. Mass. | 460.916 |
SMILES | Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 |
Structure |
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