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TargetMelanin-concentrating hormone receptor 2
LigandBDBM50172442
Substrate/Competitorn/a
Meas. Tech.ChEMBL_321623 (CHEMBL871632)
IC50 8.4±n/a nM
Citation Ulven, TFrimurer, TMReceveur, JMLittle, PBRist, ONørregaard, PKHögberg, T 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode. J Med Chem48:5684-97 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 2
Name:Melanin-concentrating hormone receptor 2
Synonyms:GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:Enzyme Catalytic Domain
Mol. Mass.:38862.16
Organism:Homo sapiens (Human)
Description:Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50172442
n/a
NameBDBM50172442
Synonyms:(E)-N-[2-(2-Dimethylamino-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide | CHEMBL196196
TypeSmall organic molecule
Emp. Form.C24H25F3N4O2
Mol. Mass.458.4761
SMILESCN(C)CCNc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Structure
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