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TargetCytochrome P450 2C19
LigandBDBM50172460
Substrate/Competitorn/a
Meas. Tech.ChEMBL_322416
IC50 33000±n/a nM
Citation Peretto IRadaelli SParini CZandi MRaveglia LFDondio GFontanella LMisiano PBigogno CRizzi ARiccardi BBiscaioli MMarchetti SPuccini PCatinella SRondelli ICenacchi VBolzoni PTCaruso PVilletti GFacchinetti FDel Giudice EMoretto NImbimbo BP Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem 48:5705-20 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2C19
Name:Cytochrome P450 2C19
Synonyms:CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:Enzyme
Mol. Mass.:55935.47
Organism:Homo sapiens (Human)
Description:P33261
Residue:490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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  Blast E-value cutoff:
BDBM50172460
n/a
NameBDBM50172460
Synonyms:1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)-biphenyl-4-yl]-cyclopropanecarboxylic acid | CHEMBL197140
TypeSmall organic molecule
Emp. Form.C26H31FO3
Mol. Mass.410.5209
SMILESCC1(C)CC(CC(C)(C)C1)Oc1ccc(cc1)-c1ccc(cc1F)C1(CC1)C(O)=O
Structure
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